What is CBD?
CBD is one of over 100 naturally occurring phytocannabinoids found in the cannabis plant. CBD is non-intoxicating, unlike its sister cannabinoid THC.
How is CBD made?
CBD is extracted from the Cannabis plant. Most CBD on the market is derived from hemp plants.
What is the difference between hemp and marijuana?
While technically hemp is marijuana, legally, hemp is defined as cannabis containing less than the federally mandated .3% THC limit.
What is the difference between Full Spectrum CBD, CBD Isolate and Broad Spectrum CBD?
Full Spectrum CBD is the full plant extract, which retains all the various cannabinoids, terpenes and flavanoids of the plant. CBD Isolate is purely isolated CBD. Broad Spectrum is Full Spectrum CBD run through a process known as chromatography to remove the THC from the extract.
How does CBD work?
CBD works by modulating the Endocannabinoid System, or ECS.
What is the ECS?
The Endocannabinoid System is an innate biological system, like the Nervous System or Cardiovascular System, that is present in all mammals and other living creatures. The ECS spans the entire body, from the brain to the gut to skin. In fact, cannabinoid receptors are the most plentiful receptors in the human body.
What is the function of the ECS?
The ECS is responsible for creating homeostasis – a stable internal environment despite external fluctuations – relaying messages that affect how we relax, eat, sleep, forget, heal and protect. ECS has two types of receptors, CB1 and CB2 and uses the endogenous cannabinoids Anandamide and 2-AG.
What functions does the ECS impact?
The ECS impacts: sleep, appetite, digestion, hunger, mood, motor control, immune functions, reproduction and fertility, pleasure and reward, pain and inflammation, memory, temperature regulation and neurogenesis. The ECS also finds and clears free radicals – electrically unstable atoms that pull electrons from molecules they interact with.
How does CBD affect the body?
- CBD acts on Anandamide as a reuptake and breakdown inhibitor, increasing Anandamide levels in the body. The name Anandamide stems from the Sanksrit word Ananda – which means, joy, bliss and delight. (1)
- CBD acts as a reuptake inhibitor for the neurotransmitter Adenosine. Adenosine directly affects anxiety and inflammation. (2)
- CBD directly stimulates serotonin via the 5HT1A receptor. The 5HT1A receptor impacts anxiety, appetite, sleep, perception of pain, mood, gut comfort and sexual behavior among others. (3)
- CBD Interacts with the TRPV1 receptor. The TRPV1 receptor mediates pain perception, inflammation and body temperature. (4)
- CBD stimulates the PPAR-Gamma receptor. The PPAR-Gamma receptor is involved in energy homeostasis, lipid uptake, insulin sensitivity and other metabolic function CBD Increases Anandamide. (5)
(1) https://pubmed.ncbi.nlm.nih.gov/27790143/ – CBD and Anandamide
(2) https://pubmed.ncbi.nlm.nih.gov/24853683/ – CBD and Adenosine
(3) https://pubmed.ncbi.nlm.nih.gov/16258853/ – CBD and 5ht1a
(4) https://www.ncbi.nlm.nih.gov/pmc/article/PMC6340993/ – Cannabis and TRPV1
(5) https://www.ncbi.nlm.nih.gov/pmc/aticles/PMC2220031/ – Cannabis on PPAR
Is CBD Legal and Safe?
- In 2017 the WHO reported that CBD posed no public health risk or abuse potential. –
- A 2011 review conducted by Mateus Machado Bergamaschi found that long term doses of up to 1500mg of CBD a day were well tolerated in humans.
- In fact, the high rate of abuse and overdose associated with opioids make CBD a considerably safer alternative or addition to opioids for pain management.
- Although side effects are rare, the most commonly reported side effects include dizziness, lethargy, hyperactivity, loose stools, jitteriness and increased heart rate.
- Always consult a doctor about potential interactions with drugs you are currently using.
- CBD derived from hemp (Cannabis with a THC content <.3%) was made federally legal in all 50 US States under the 2018 Farm Bill.